ABSTRACT
Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis and this disease is a genetically determined disturbance of epidermal proliferation. It is characterized by acquired, slowly progressive pigmented lesions that primarily involve the great skin folds and flexural areas such as the axilla, neck, limb flexures, the inframammary area and the inguinal folds. The vulva is an unusual location for DDD. A 41-year-old woman presented with a 10-year history of multiple, small, reticulated and brownish macules distributed symmetrically on the bilateral external genital regions. We found no other similarly pigmented skin lesions on her body, including the flexural areas. There was no known family history of similar eruptions or pigmentary changes. The histologic examination showed irregular rete ridge elongation with a filiform or antler-like pattern and basilar hyperpigmentation on the tips. Fontana-Masson staining showed increased pigmentation of the rete ridges and the S100 protein staining did not reveal an increased number of melanocytes in the epidermis. From these findings, we diagnosed this lesion as DDD.
Subject(s)
Adult , Female , Humans , Axilla , Dichlorodiphenyldichloroethane , Epidermis , Extremities , Hyperpigmentation , Melanocytes , Neck , Pigmentation , Skin , Skin Diseases, Genetic , Skin Diseases, Papulosquamous , VulvaABSTRACT
Hidroacanthoma simplex is a benign tumor believed to arise from the uppermost segment of the intradermal eccrine duct and the acrosyringium, and histologically shows intraepidermal focal growth. A malignant counterpart to this tumor is rare and named malignant hidroacanthoma simplex or porocarcinoma in situ. We report a case of atypical hidroacanthoma simplex, which is considered to be a malignant transformation of benign hidroacanthoma simplex in a 83- year-old female.
Subject(s)
Female , Humans , ImmunohistochemistryABSTRACT
BACKGROUND: Human nails bear longitudinal furrows on both upper and lower surface. These furrows are formed as the nails grow and correspond to parallel dermal ridges irregularly distributed on the nail bed. Often there is fungal invasion in a longitudinal narrow band according to the furrows of the nail bed, clinically recognized streak type onychomycosis. OBJECTIVE: Our purpose was to investigate the clinical features, causative organisms, and predisposing factors and to evaluate the treatment responses of oral antifungal agent in streak type onychomycosis. METHODS: The study was conducted with 387 cases of onycomycosis (45 cases of streak type, 342 cases of non-streak type) and 50 normal controls examined at Department of Dermatology, Hanyang University Guri Hospital from June, 2001 to May, 2004. Streak type onychomycosis was devided into three clinical presentations: distal type (20 cases), lateral type (19 cases), and multiple type (6 cases). RESULTS: In the groups of distal and multiple type of streak type onychomycosis, the longitudinal nail furrows were deep compared to the groups of non-streak type onychomycosis and normal control (p 0.05). In the groups of distal and lateral type of streak type onychomycosis, the treatment responses were poor compared to the group of non-streak type onychomycosis (p< 0.05). CONCLUSION: Treatment response is poor in streak type onychomycosis, therefore, extra treatments in addition to oral antifungal agents should be considered. If the patients who have deep longitudinal nail furrow are affected with tinea pedis, effective therapies in early stage should be considered to prevent to progress to streak type onychomycosis.